The first cover image (above left), features the article titled A noninvasive method for the determination of in vivo mitral valve leaflet strains, which explores a "noninvasive method for the determination of mitral valve (MV) leaflet deformation, which is a critical metric of MV function." MV function has an essential role in many applications for the treatment of MV disease. Authored by Amir H. Khalighi, Bruno V. Rego, Andrew Drach, Robert C. Gorman, Joseph H. Gorman and Michael S. Sacks.

A second cover image (above middle) features the article titled The Three-Dimensional Microenvironment of the Mitral Valve: Insights into the Effects of Physiological Loads, explores the mechanical interactions between mitral valve interstitial cells (MVIC) and their local collagen fibers. Authored by Salma Ayoub, Karen C. Tsai, Amir Khalighi and Michael S. Sacks.

A third cover image (above right) features the article titled Development of a Functionally Equivalent Model of the Mitral Valve Chordae Tendineae Through Topology Optimization, which explores methods to "to produce functionally equivalent MV chordae tendineae (MVCT) models that can be built from the image-based MV leaflet geometry alone." This is helpful in situations where the MVCT geometry cannot be properly captured for modeling. Authored by Amir H. Khalighi, Bruno V. Rego, Andrew Drach, Robert C. Gorman, Joseph H. Gorman III, Michael S. Sacks